The fourth issue of the ARRIGE newsletter has been just published. It corresponds to October 2021 and features several aspects on Clinical Applications of Genome Editing. It includes an Editorial written by Lluis Montoliu, President of ARRIGE, and articles contributed by S. Eben Kirskey, André Choulika and Susana Simoes et al. This newsletter also includes free commentaries from Alta Charo, Ariel Lindler and Dusan Misevic, and some interesting community news and contributions. Finally, it also includes the outcome of the recent ARRIGE BOARD 2021 elections, with the new elected ARRIGE Board.