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CRISPR

The ARRIGE initiative featured in Nature Biotechnology

By arrige, CRISPR, genome editing, in English, publicactionNo Comments
Nature Biotechnology 36, 485 (2018). doi:10.1038/nbt0618-485

The ARRIGE initiative is featured in this News&Comment article by Eric Smalley in Nature Biotechnology. Indeed a big challenge the one we have ahead of us but an unavoidable one, if we believe in the responsible use of genome editing techniques and in the engagement of all stakeholders that are involved in the process. Hands to work!.

Unexpected mutations were expected and unrelated to CRISPR

By arrige, CRISPR, genome editing, in vivo experiments, off-target mutations, publicactionNo Comments
Scheme illustrating the effect of spontaneous mutations and genetic drift responsible for the divergence of animal subcolonies bred independently (Figure from Montoliu and Whitelaw, Transgenic Research, 2018, online May 31).

Bruce Whitelaw (The Roslin Institute, Edinburgh, Scotland, UK) and I, we have just published a commentary in the scientific journal Transgenic Research discussing the case of the Nature Methods paper by Schaefer et al. 2017 who initially reported the identification of numerous off-target sites altered after a genome-editing experiment in vivo, in mice. This paper has recently been retracted by the journal (March 30). As indicated by the authors in this commentary: “The most plausible explanation for the vast majority of the reported unexpected mutations were the expected underlying genetic polymorphisms that normally accumulate in two different colonies of the same mouse strain which occur as a result of spontaneous mutations and genetic drift. Therefore, the reported mutations were most likely not related to CRISPR-Cas9 activity.

ARRIGE Kick-Off meeting: Lauren Roberts & Louise James on involving patients

By arrige, CRISPR, genome editing, in English, Kick-Off meeting, meeting, patients, videoNo Comments

Presentation by Lauren Roberts and Louise James (Genetic Alliance UK) on involving patients in the discussion of issues raised by genome editing technology at the ARRIGE Kick-Off meeting. ARRIGE Kick-Off meeting was held on 23 March 2018 at the Région Île-de-France Parliament, in Paris, France.

ARRIGE Kick-Off meeting video files available from the new ARRIGE YouTube channel. All 21 video files can be played and watched in the correct order through the ARRIGE Kick-Off meeting YouTube Play List.

More information about ARRIGE can be obtained from the ARRIGE web site.

ARRIGE Kick-Off meeting: Filipa Ferraz de Oliveira on Animal issues raised by GE technology

By arrige, CRISPR, genome editing, in vivo experiments, Kick-Off meeting, meeting, presentations, videoNo Comments

Presentation by Filipa Ferraz de Oliveira (European Research Council, Ethics sector, Brussels, Belgium) on the Animal issues raised by genome editing technology at the ARRIGE Kick-Off meeting. ARRIGE Kick-Off meeting was held on 23 March 2018 at the Région Île-de-France Parliament, in Paris, France.

ARRIGE Kick-Off meeting video files available from the new ARRIGE YouTube channel. All 21 video files can be played and watched in the correct order through the ARRIGE Kick-Off meeting YouTube Play List.

More information about ARRIGE can be obtained from the ARRIGE web site.

ARRIGE Kick-Off meeting: Andreas Kurtz on Environmental issues raised by GE technology

By arrige, CRISPR, Kick-Off meeting, presentations, safety, videoNo Comments

Presentation by Andreas Kurtz (Charité Hospital, Berlin, Germany and European Group of Ethics, EGE) at the ARRIGE Kick-Off meeting on the Environmental issues raised by genome editing technology. ARRIGE Kick-Off meeting was held on 23 March 2018 at the Région Île-de-France Parliament, in Paris, France.

ARRIGE Kick-Off meeting video files available from the new ARRIGE YouTube channel. All 21 video files can be played and watched in the correct order through the ARRIGE Kick-Off meeting YouTube Play List.

More information about ARRIGE can be obtained from the ARRIGE web site.

ARRIGE Kick-Off meeting: Peter Mills on Human issues raised by GE technology

By arrige, CRISPR, genome editing, Kick-Off meeting, presentations, review, videoNo Comments

Presentation by Peter Mills (Nuffield Council on Bioethics, London, UK) on Human issues raised by genome editing technology at the ARRIGE Kick-Off meeting. ARRIGE Kick-Off meeting was held on 23 March 2018 at the Région Île-de-France Parliament, in Paris, France.

ARRIGE Kick-Off meeting video files available from the new ARRIGE YouTube channel. All 21 video files can be played and watched in the correct order through the ARRIGE Kick-Off meeting YouTube Play List.

More information about ARRIGE can be obtained from the ARRIGE web site.

ARRIGE Kick-Off meeting: Hervé Chneiweiss on presentation of ARRIGE

By arrige, constitution, CRISPR, genome editing, Kick-Off meeting, meeting, presentations, review, videoNo Comments

Talk by Hervé Chneiweiss (INSERM Ethics Committee) on the Ethics of the genome editing technologies: presentation of ARRIGE, at the ARRIGE Kick-Off meeting. ARRIGE Kick-Off meeting was held on 23 March 2018 at the Région Île-de-France Parliament, in Paris, France.

ARRIGE Kick-Off meeting video files available from the new ARRIGE YouTube channel. All 21 video files can be played and watched in the correct order through the ARRIGE Kick-Off meeting YouTube Play List.

More information about ARRIGE can be obtained from the ARRIGE web site