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Statement about EC proposal on New Genomic Techniques regulation in plants

By Blog, CRISPR, genome editing, in English, News, regulation, reports, safety

New ARRIGE Scientific Committee Statement

Josep Casacuberta, member of the ARRIGE Scientific Committee and expert in plant molecular biology and regulation in plants, has written this summary report that has been adopted by the ARRIGE Scientific Committee as an Statement about European Parliament vote on new genomic techniques (NGTs) regulation in plants. Document is available here.

The ARRIGE initiative featured in Nature Biotechnology

By arrige, CRISPR, genome editing, in English, publicactionNo Comments
Nature Biotechnology 36, 485 (2018). doi:10.1038/nbt0618-485

The ARRIGE initiative is featured in this News&Comment article by Eric Smalley in Nature Biotechnology. Indeed a big challenge the one we have ahead of us but an unavoidable one, if we believe in the responsible use of genome editing techniques and in the engagement of all stakeholders that are involved in the process. Hands to work!.

Unexpected mutations were expected and unrelated to CRISPR

By arrige, CRISPR, genome editing, in vivo experiments, off-target mutations, publicactionNo Comments
Scheme illustrating the effect of spontaneous mutations and genetic drift responsible for the divergence of animal subcolonies bred independently (Figure from Montoliu and Whitelaw, Transgenic Research, 2018, online May 31).

Bruce Whitelaw (The Roslin Institute, Edinburgh, Scotland, UK) and I, we have just published a commentary in the scientific journal Transgenic Research discussing the case of the Nature Methods paper by Schaefer et al. 2017 who initially reported the identification of numerous off-target sites altered after a genome-editing experiment in vivo, in mice. This paper has recently been retracted by the journal (March 30). As indicated by the authors in this commentary: “The most plausible explanation for the vast majority of the reported unexpected mutations were the expected underlying genetic polymorphisms that normally accumulate in two different colonies of the same mouse strain which occur as a result of spontaneous mutations and genetic drift. Therefore, the reported mutations were most likely not related to CRISPR-Cas9 activity.

ARRIGE coverage from Spain

By arrige, genome editing, in Spanish, reportsNo Comments
Article about the ARRIGE kick-off meeting published by the Spanish newspaper DIARIO MEDICO

The Spanish newspaper DIARIO MEDICO, specialized in the field of health and regularly read by many professional colleagues including those from Hospitals, Clinics and Biomedical research centres in Spain, covered the launching of the ARRIGE and our kick-off meeting in a recent article, written by José A. Plaza and published on April 8, 2018. The article is in Spanish and is entitled: “Toward an international governance in CRISPR“.