ARRIGE Scientific Committee white paper on Ethics of CRISPR Gene Therapy
The ARRIGE Scientific Committee has prepared a white paper on the Ethics of CRISPR Gene Therapy. You can find other documents and statements from ARRIGE and the Scientific Committee in the Documents section of this ARRIGE web site.
New ARRIGE Scientific Committee Statement
Josep Casacuberta, member of the ARRIGE Scientific Committee and expert in plant molecular biology and regulation in plants, has written this summary report that has been adopted by the ARRIGE Scientific Committee as an Statement about European Parliament vote on new genomic techniques (NGTs) regulation in plants. Document is available here.
The ARRIGE Scientific Committee just released today a statement about EC proposal on New Genomic Techniques regulation in plants
The ARRIGE initiative is featured in this News&Comment article by Eric Smalley in Nature Biotechnology. Indeed a big challenge the one we have ahead of us but an unavoidable one, if we believe in the responsible use of genome editing techniques and in the engagement of all stakeholders that are involved in the process. Hands to work!.
Bruce Whitelaw (The Roslin Institute, Edinburgh, Scotland, UK) and I, we have just published a commentary in the scientific journal Transgenic Research discussing the case of the Nature Methods paper by Schaefer et al. 2017 who initially reported the identification of numerous off-target sites altered after a genome-editing experiment in vivo, in mice. This paper has recently been retracted by the journal (March 30). As indicated by the authors in this commentary: “The most plausible explanation for the vast majority of the reported unexpected mutations were the expected underlying genetic polymorphisms that normally accumulate in two different colonies of the same mouse strain which occur as a result of spontaneous mutations and genetic drift. Therefore, the reported mutations were most likely not related to CRISPR-Cas9 activity.“
The Spanish newspaper DIARIO MEDICO, specialized in the field of health and regularly read by many professional colleagues including those from Hospitals, Clinics and Biomedical research centres in Spain, covered the launching of the ARRIGE and our kick-off meeting in a recent article, written by José A. Plaza and published on April 8, 2018. The article is in Spanish and is entitled: “Toward an international governance in CRISPR“.
